Knowledge · Nutrition
Resveratrol and immune signalling: STAT3, NF-κB and the contradictions of SIRT1
STAT3, NF-κB and NAD⁺-dependent deacetylation; conflicting Th17/Treg findings, pharmacokinetics and positive and negative clinical trials.
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Knowledge · General
Xenohormesis: plant stress, cellular adaptation and the limits of longevity evidence
How plant defense chemistry interacts with Nrf2, AMPK, sirtuins and autophagy. Biosynthesis, agroecology, metabolites, pharmacokinetics and the limits of translating mechanisms into human health and lifespan.
Knowledge · Supplements
Resveratrol and pterostilbene: stilbene chemistry, SIRT1, and the limits of bioavailability
The chemistry of two stilbenes, conjugation and free aglycone, conditional SIRT1 allostery, the indirect PDE–AMPK pathway, clinical markers, and safety boundaries.