Bile-acid synthesis and conjugation, BSH/bai, enterohepatic transport, FXR–FGF19 and TGR5. Lipids, GLP-1, thermogenesis, MASH trials and evidence limits.

October 8, 2026

Knowledge · General

SIRT3: mitochondrial deacetylation, metabolism and redox defense

How SIRT3 uses NAD⁺ to remove acetyl marks and regulate LCAD, ACSS1, HMGCS2, IDH2 and SOD2. Structure, import, respiration, mPTP, deficiency models and the limits of clinical claims about supplements and exercise.

October 8, 2026

Knowledge · General

NAD⁺ in aging: compartments, CD38, PARP1, SARM1 and intervention limits

NAD⁺ synthesis and consumption across cellular compartments, the structural and kinetic logic of CD38/PARP1/SARM1, and critical reading of human NR and NMN studies.

October 8, 2026

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Bile acids, FXR and TGR5: the gut–liver axis

SIRT3: mitochondrial deacetylation, metabolism and redox defense

NAD⁺ in aging: compartments, CD38, PARP1, SARM1 and intervention limits