NLRP3 assembly, priming, K⁺ efflux, IL-1β/IL-18 maturation, and clinical evidence are considered separately. Inflammaging is not one sensor, and IL-1β blockade is not direct NLRP3 inhibition.

October 9, 2026

Knowledge · Supplements

Magnesium L-Threonate: Brain Access, Synaptic Function, and the Limits of Clinical Evidence

How magnesium L-threonate relates to brain magnesium, NMDA receptors, and synaptic plasticity. This review covers the compound’s chemistry, transport across barriers, animal and human memory studies, dosing, and safety without overstating the evidence.

October 8, 2026

Knowledge · Supplements

Exogenous GABA: the BBB, gut receptors, vagus, stress and sleep

An in-depth scientific analysis of oral GABA: chemistry, barrier transport, GABA_A/GABA_B receptors, the gut–brain axis and human trials. A practical account of mechanisms, research doses and safety limits without promises of a universal effect.

October 2, 2026

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The NLRP3 Inflammasome: Assembly, IL-1β, and the Limits of the Inflammaging Model

Magnesium L-Threonate: Brain Access, Synaptic Function, and the Limits of Clinical Evidence

Exogenous GABA: the BBB, gut receptors, vagus, stress and sleep