A detailed account of reversible AChE inhibition, pharmacokinetics, NMDA, mitochondria, Nrf2 and APP. Dementia trials are distinguished from cell and animal findings, with safety, interactions and practical assessment of memory complaints.

October 3, 2026

Knowledge · Supplements

Ashwagandha: withanolides, the HPA axis, cortisol, and the limits of clinical use

An in-depth examination of withanolide chemistry, GABA signaling, the HPA axis, and the glucocorticoid receptor, distinguishing experimental mechanisms from clinical outcomes and the risks of ashwagandha.

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Knowledge · Nutrition

Vitamin E: Tocopherols, Membrane Protection, and Safe Use

How the body selects α-tocopherol, its role in lipid membranes, and the causes of deficiency. A deep dive into SELECT, heart, liver, vision, and cognitive research with dosages and outcomes; dietary requirements, IU units, tolerable upper limits, and drug interactions.

September 2, 2026

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Huperzine A: acetylcholinesterase and limits of neuroprotection

Ashwagandha: withanolides, the HPA axis, cortisol, and the limits of clinical use

Vitamin E: Tocopherols, Membrane Protection, and Safe Use