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hs-CRP: C-reactive protein structure, local inflammation, and vascular risk

Pentameric and monomeric CRP structure, calcium and phosphocholine, complement regulation, vascular effects, and the limits of causal inference from hs-CRP. Positive and negative cardiovascular trials.

October 9, 2026

Interleukin-6: receptor context, trans-signaling, and the limits of selective therapy

How IL-6 receptors, ADAM10/17 proteolysis, and JAK–STAT3 shape tissue responses, what olamkicept trials found, and why selectivity has limits.

October 9, 2026

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hs-CRP: C-reactive protein structure, local inflammation, and vascular risk

Interleukin-6: receptor context, trans-signaling, and the limits of selective therapy