Knowledge · Nutrition
Leptin resistance: hypothalamic inflammation, SOCS3, and POMC
Leptin and LEPR structure, JAK2/STAT3, PI3K/FoxO1, AMPK, POMC processing, and MC4R. How SOCS3, PTP1B, TCPTP, glia, ER stress, and brain delivery affect signaling; distinctions between animals, human obesity, and weight-loss adaptation.