Leptin and LEPR structure, JAK2/STAT3, PI3K/FoxO1, AMPK, POMC processing, and MC4R. How SOCS3, PTP1B, TCPTP, glia, ER stress, and brain delivery affect signaling; distinctions between animals, human obesity, and weight-loss adaptation.

October 8, 2026

Knowledge · Mental health

Neuroinflammation and the kynurenine pathway: microglia, KYNA, and QUIN

How immune signals direct tryptophan into the kynurenine pathway, how astrocytic and microglial branches differ, and where clinical conclusions from biochemistry end.

October 8, 2026

Knowledge · Supplements

Baikal skullcap: baicalin, GABA receptors, and neuroinflammation

How Scutellaria baicalensis flavones undergo intestinal metabolism and affect GABA_A, microglia, and lipid oxidation. Molecular pathways, formulas, limits of evidence on sleep and neuroprotection, interactions, and safety.

October 4, 2026

All materials

Material type

Area

Popular tags

Leptin resistance: hypothalamic inflammation, SOCS3, and POMC

Neuroinflammation and the kynurenine pathway: microglia, KYNA, and QUIN

Baikal skullcap: baicalin, GABA receptors, and neuroinflammation