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Knowledge · Nutrition

Resveratrol and immune signalling: STAT3, NF-κB and the contradictions of SIRT1

STAT3, NF-κB and NAD⁺-dependent deacetylation; conflicting Th17/Treg findings, pharmacokinetics and positive and negative clinical trials.

October 9, 2026
Knowledge · General

Xenohormesis: plant stress, cellular adaptation and the limits of longevity evidence

How plant defense chemistry interacts with Nrf2, AMPK, sirtuins and autophagy. Biosynthesis, agroecology, metabolites, pharmacokinetics and the limits of translating mechanisms into human health and lifespan.

October 8, 2026
Knowledge · Supplements

Resveratrol and pterostilbene: stilbene chemistry, SIRT1, and the limits of bioavailability

The chemistry of two stilbenes, conjugation and free aglycone, conditional SIRT1 allostery, the indirect PDE–AMPK pathway, clinical markers, and safety boundaries.

October 8, 2026