How the composition of Melissa officinalis relates to GABA-T, cholinergic activity, and autonomic symptoms. Chemistry, biosynthesis, pharmacokinetics, clinical studies, thyroid experiments, and how to read dosing regimens safely.

October 8, 2026

Knowledge · Supplements

Exogenous GABA: the BBB, gut receptors, vagus, stress and sleep

An in-depth scientific analysis of oral GABA: chemistry, barrier transport, GABA_A/GABA_B receptors, the gut–brain axis and human trials. A practical account of mechanisms, research doses and safety limits without promises of a universal effect.

October 2, 2026

Knowledge · Supplements

Ashwagandha: withanolides, the HPA axis, cortisol, and the limits of clinical use

An in-depth examination of withanolide chemistry, GABA signaling, the HPA axis, and the glucocorticoid receptor, distinguishing experimental mechanisms from clinical outcomes and the risks of ashwagandha.

October 2, 2026

Knowledge · Supplements

L-theanine: alpha rhythms, glutamate, stress, and caffeine

An in-depth examination of L-theanine chemistry, transport, synaptic models, and human trials: what is known about attention, anxiety, sleep, dosing, and safety, and which mechanisms cannot yet be translated into clinical practice.

October 2, 2026