Knowledge · Nutrition
Carnitine palmitoyltransferase 1: the carnitine shuttle, malonyl-CoA and β-oxidation
An in-depth monograph on the delivery of long-chain fatty acids into mitochondria, tissue-specific CPT1 isoforms, and regulation by malonyl-CoA. It examines catalysis, AMPK–ACC, β-oxidation, energy calculations, metabolic flexibility, and inherited defects. Clinical and sports studies of carnitine, the microbial TMAO pathway, and pharmacological approaches are considered within the limits of the evidence.