How berberine affects AMPK, MLCK, ZO-1, and occludin in epithelial injury models; pharmacokinetics, separate IBS-D and ulcerative-colitis findings, and limits of clinical inference.

October 9, 2026

Knowledge · Nutrition

Dietary lectins: glycan binding, the intestinal barrier, and real-world exposure

How WGA and PHA bind glycans, what permeability models show, why undercooked beans can cause acute poisoning, and why clinical effects of cooked wheat remain uncertain.

October 9, 2026

Knowledge · Nutrition

Intestinal alkaline phosphatase: LPS chemistry, the microbiota, and clinical limits

ALPI enzymology, lipid A and ATP dephosphorylation, microbiota, regulation, and human trials: negative primary outcomes in STOP-AKI and REVIVAL and limits of ulcerative-colitis data.

October 9, 2026

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Berberine and the Intestinal Barrier: AMPK, Tight Junctions, and the Limits of Clinical Evidence

Dietary lectins: glycan binding, the intestinal barrier, and real-world exposure

Intestinal alkaline phosphatase: LPS chemistry, the microbiota, and clinical limits