Telomere protection, DDR and p53–PGC connect genome status with mitochondrial energy. Shelterin, BER, mouse experiments, telomere disorders and the limits of intervention claims.

October 8, 2026

Knowledge · Supplements

Resveratrol and pterostilbene: stilbene chemistry, SIRT1, and the limits of bioavailability

The chemistry of two stilbenes, conjugation and free aglycone, conditional SIRT1 allostery, the indirect PDE–AMPK pathway, clinical markers, and safety boundaries.

October 8, 2026

Knowledge · Supplements

Pyrroloquinoline Quinone (PQQ): Redox Chemistry, CREB–PGC-1α, and the Limits of Clinical Evidence

From a bacterial quinone cofactor and cellular mitochondrial biogenesis to cardiac and brain models, small human studies, and toxicological limits.

October 8, 2026