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Knowledge · General

Mitochondrial dynamics: DRP1, MFN2, OPA1 and mitophagy

Fusion and fission mechanochemistry, ER contacts, DRP1 regulation and PINK1–Parkin; inherited disorders and limits of preclinical interventions.

October 8, 2026
Knowledge · General

Mitochondrial DNA: damage, heteroplasmy and innate immunity

Mitochondrial-genome architecture, TFAM, mtROS, BER/POLG, deletions and tissue thresholds; ageing models, cGAS–STING/TLR9/NLRP3, mitophagy, biogenesis and the limits of mtDNA editing.

October 8, 2026
Knowledge · Supplements

Urolithin A: PINK1/Parkin mitophagy, muscle function, and limits of the evidence

From the microbial ellagitannin cascade to ubiquitin-mediated mitophagy and human trials: primary outcomes, secondary signals, pharmacokinetics, and urolithin A safety.

October 8, 2026