How complement pathways generate C3b, anaphylatoxins and C5b–9; why endothelial injury is tissue-specific and what positive, negative and retracted clinical findings show.

October 9, 2026

Knowledge · General

The endothelial glycocalyx: hyaluronan, shear stress, and the vascular barrier

HS, HA, syndecan and glypican architecture; shear signaling, eNOS, SOD3, and antithrombin. Revised Starling forces, rheology, renal and brain barriers, indirect PBR and biomarkers, and positive and negative repair trials.

October 8, 2026

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The complement system: C3a, C5a and the boundary between protection and injury

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The endothelial glycocalyx: hyaluronan, shear stress, and the vascular barrier